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US, Hungarian scientists win Nobel Prize for research that led to Covid vaccines

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Scientists Katalin Kariko of Hungary and Drew Weissman of the United States respectively won the 2023 Nobel Prize in Physiology or Medicine for discoveries enabling the development of mRNA Covid-19 vaccines, the award-giving body has announced.

“The 2023 Nobel Prize in Physiology or Medicine has been awarded to Katalin Kariko and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against Covid-19,” the body said on Monday

The prize, among the most prestigious in the scientific world, is selected by the Nobel Assembly of Sweden’s Karolinska Institute Medical University and also comes with 11 million Swedish crowns (about $1 million).

Kariko was senior vice president and head of RNA protein replacement at BioNTech until 2022 and has since acted as an adviser to the company. She is also a professor at the University of Szeged in Hungary and adjunct professor at the University of Pennsylvania’s Perelman School of Medicine.

Weissman is professor in vaccine research at the Perelman School.

Kariko found a way to prevent the immune system from launching an inflammatory reaction against lab-made mRNA, previously seen as a major hurdle against any therapeutic use of mRNA.

Together with Weissman, she showed in 2005 that adjustments to nucleosides, the molecular letters that write the mRNA’s genetic code, can keep the mRNA under the immune system’s radar.

‘Major impact on society’

“So this year’s Nobel Prize recognises their basic science discovery that fundamentally changed our understanding of how mRNA interacts with the immune system and had a major impact on society during the recent pandemic,” said Rickard Sandberg, member of the Nobel Assembly at Karolinska Institute

The medicine prize kicks off this year’s awards with the remaining five to be unveiled in the coming days.

The prizes, first handed out in 1901, were created by Swedish dynamite inventor and wealthy businessman Alfred Nobel, and are awarded for achievements in science, literature and peace, and in later years also for economics.

The Swedish king will present the prizes at a ceremony in Stockholm on Dec. 10, the anniversary of Nobel’s death, followed by a lavish banquet at city hall.

Last year’s medicine prize went to Swede Svante Paabo for sequencing the genome of the Neanderthal, an extinct relative of present-day humans, and for discovering a previously unknown human relative, the Denisovans.

Other past winners include Alexander Fleming, who shared the 1945 prize for the discovery of penicillin, and Karl Landsteiner in 1930 for his discovery of human blood groups.

Health

Health services to be expanded urgently for return refugees at Torkham border

Since 1 April at least 44,900 people have returned, with around 58% of them children, according to the UN Refugee Agency (UNHCR).

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Afghanistan’s health ministry said Tuesday it is expanding health services at Torkham in Nangarhar to cope with the growing number of returning refugees from Pakistan.

According to a statement issued by the ministry, a coordination meeting was recently held to discuss the expansion of health services.

The meeting was chaired by Mawlawi Aminullah Sharif, Director of Public Health in Nangarhar Province, and attended by representatives from various organizations including the World Health Organization (WHO), UNICEF, and other partners.

The meeting focused on improving emergency preparedness and response, enhancing healthcare support for returnees, and addressing current operational challenges, the statement read.

Officials emphasized the urgent need to strengthen health service delivery in response to the growing number of returning citizens.

As a key outcome, participants agreed to increase the number of health facilities and medical staff at the border. This decision aims to ensure timely access to medical care for all returnees and to better manage the health-related pressures caused by the ongoing influx.

Tens of thousands of Afghans are facing dire conditions in makeshift camps after crossing the border from Pakistan, an Islamic Relief assessment team reported on Monday.

“Many are arriving in Afghanistan without any shelter, food, cash or water, and families told us they had to leave all their possessions – including animals and household utensils – behind as they cannot afford to bring them,” Islamic Relief said in the report.

Ramin Sadat from Islamic Relief was part of an assessment team at the Torkham border crossing in eastern Afghanistan. He said this new wave of returning refugees “is unlike anything I’ve seen before. People arrive in droves, covered in dust, crammed onto trucks, and facing a barren border with no basic services in sight. The first thing that greets them is a harsh, windy storm swirling with dust.”

Tens of thousands of families are expected to arrive in the coming days and months, in the wake of the Pakistan government’s announcement that all undocumented individuals and holders of Afghan Citizen Cards (ACC) must leave the country by 31 March 2025 or face deportation.

Since 1 April at least 44,900 people have returned, with around 58% of them children, according to the UN Refugee Agency (UNHCR).

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Aid cuts could leave more women dying in pregnancy and birth, UN says

The cuts have had “pandemic-like effects” on health systems globally and could have a “more structural, deep-seated effect”, says WHO director

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Cuts to aid budgets are threatening to undermine years of progress in reducing the number of women dying during pregnancy and childbirth, and could lead to a rise in deaths, the United Nations has warned.

Globally, there was a 40% decline in maternal deaths between 2000 and 2023, a report by UN agencies including the World Health Organization (WHO) showed on Monday, largely due to better access to essential health services.

That could now go into reverse, the WHO said in a statement accompanying the report which did not mention specific cuts but came in the wake of a foreign aid freeze by the U.S. government and the ending of funding through the United States Agency for International Development (USAID) for many programmes.

Other donor countries including Britain have also announced plans to cut aid budgets.

“One of the headline messages is that the funding cuts risk not only that progress, but we could have a shift backward,” said Dr Bruce Aylward, Assistant Director-General, Universal Health Coverage at the WHO.

The cuts have had “pandemic-like effects” on health systems globally and could have a “more structural, deep-seated effect,” Aylward added.

The WHO said the cuts were already rolling back vital services for maternal, newborn and child health in many countries, reducing staff numbers, closing facilities and disrupting supply chains for supplies including treatments for hemorrhage and pre-eclampsia.

Cuts to other areas, such as malaria and HIV treatment, would also impact maternal survival, the UN said.

Even before the aid cuts led by the United States, things were backsliding in some countries, and progress has slowed globally since 2016, the report said.

In 2023, despite recent progress, a woman still died roughly every two minutes – around 260,000 in total that year – from complications that were mainly preventable and treatable, it added.

The situation was particularly bad in countries affected by conflict or natural disaster, although the U.S. itself is one of only four countries to have seen its maternal mortality rate increase significantly since 2000, alongside Venezuela, the Dominican Republic and Jamaica.

The COVID-19 pandemic also had an impact, the report said: 40,000 more women died due to pregnancy or childbirth in 2021, bringing the total number of deaths that year to 322,000.

“While this report shows glimmers of hope, the data also highlights how dangerous pregnancy still is in much of the world today – despite the fact that solutions exist,” WHO Director-General Tedros Adhanom Ghebreyesus said.

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Global organizations warn of health crisis due to aid cuts in Afghanistan

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Global organizations are raising alarms about the impact of aid cuts on Afghanistan’s health sector and the reduction in funding for humanitarian organizations operating in the country.

UN-affiliated bodies have stated that the complete suspension of aid from the United States and the reduction of the 2025 budget could lead to the closure or suspension of nearly 2,000 healthcare centers across Afghanistan.

The United Nations Office for the Coordination of Humanitarian Affairs (OCHA) has further warned that if only 25 percent of the required funding is provided, 7 million out of the 9.3 million people in need of medical services will be left without access to healthcare.

The report highlights that without immediate and sufficient funding, child mortality rates could rise sharply, as malnutrition remains one of the leading causes of death for children under the age of five.

The World Food Programme (WFP) has also warned that Afghanistan is facing a severe malnutrition crisis among children, with the number of malnourished children expected to reach 3.5 million by 2025.

Recent reports from the WFP reveal that 8 out of 10 families in Afghanistan are unable to afford a sufficient diet, and 3 out of 4 families are being forced to borrow money to purchase basic food items.

UN agencies have stressed the urgent need for the international community to address the humanitarian crisis in Afghanistan and provide the necessary aid.

This comes after Afghanistan’s Ministry of Economy dismissed reports from some international organizations about the growing poverty in the country, labeling them as exaggerated and far from reality.

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