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US, Hungarian scientists win Nobel Prize for research that led to Covid vaccines

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Scientists Katalin Kariko of Hungary and Drew Weissman of the United States respectively won the 2023 Nobel Prize in Physiology or Medicine for discoveries enabling the development of mRNA Covid-19 vaccines, the award-giving body has announced.

"The 2023 Nobel Prize in Physiology or Medicine has been awarded to Katalin Kariko and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against Covid-19," the body said on Monday

The prize, among the most prestigious in the scientific world, is selected by the Nobel Assembly of Sweden's Karolinska Institute Medical University and also comes with 11 million Swedish crowns (about $1 million).

Kariko was senior vice president and head of RNA protein replacement at BioNTech until 2022 and has since acted as an adviser to the company. She is also a professor at the University of Szeged in Hungary and adjunct professor at the University of Pennsylvania’s Perelman School of Medicine.

Weissman is professor in vaccine research at the Perelman School.

Kariko found a way to prevent the immune system from launching an inflammatory reaction against lab-made mRNA, previously seen as a major hurdle against any therapeutic use of mRNA.

Together with Weissman, she showed in 2005 that adjustments to nucleosides, the molecular letters that write the mRNA’s genetic code, can keep the mRNA under the immune system’s radar.

'Major impact on society'

"So this year's Nobel Prize recognises their basic science discovery that fundamentally changed our understanding of how mRNA interacts with the immune system and had a major impact on society during the recent pandemic," said Rickard Sandberg, member of the Nobel Assembly at Karolinska Institute

The medicine prize kicks off this year's awards with the remaining five to be unveiled in the coming days.

The prizes, first handed out in 1901, were created by Swedish dynamite inventor and wealthy businessman Alfred Nobel, and are awarded for achievements in science, literature and peace, and in later years also for economics.

The Swedish king will present the prizes at a ceremony in Stockholm on Dec. 10, the anniversary of Nobel's death, followed by a lavish banquet at city hall.

Last year's medicine prize went to Swede Svante Paabo for sequencing the genome of the Neanderthal, an extinct relative of present-day humans, and for discovering a previously unknown human relative, the Denisovans.

Other past winners include Alexander Fleming, who shared the 1945 prize for the discovery of penicillin, and Karl Landsteiner in 1930 for his discovery of human blood groups.

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Excluding Afghan women from medical institutes threatens the future of health care in the country: MSF

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The Islamic Emirate of Afghanistan’s (IEA) decision to bar women from studying in medical institutes will have far-reaching consequences for women’s health in the country, Médecins Sans Frontières (Doctors Without Borders) said on Friday.

This is another stage in the removal of women from public and professional life in Afghanistan. Already, there is an insufficient number of female health care workers in the country, impacting the availability of health care, especially given the separation of hospital wards by gender. New constraints will further restrict access to quality health care and pose serious dangers to its availability in the future, MSF said in a statement.

“There is no health care system without educated female health practitioners,” said Mickael Le Paih, MSF’s country representative in Afghanistan. “At MSF, more than 50 percent of our medical staff are women. The decision to bar women from studying at medical institutes will further exclude them from both education and the impartial provision of health care.”

The medical needs in Afghanistan are huge, and more female Afghan medical staff need to be trained to address them. For this to happen, women need to have access to education. Education restrictions for women and girls put in place in 2024, 2022, and 2021 considerably reduce the number of female medical staff in the future, MSF said.

“If no girls can attend secondary school, and no women can attend university or medical institutes, where will the female health professionals of the future come from and who will attend to Afghan women when they are at their most vulnerable?” said Le Paih. “For essential services to be available to all genders, they must be delivered by all genders.”

Recently, there have been reports that the leader of the Islamic Emirate has ordered the closure of medical institutes to women. The Islamic Emirate has not yet officially commented on this matter.

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Afghanistan’s health minister visits disease control center during China visit

Jalali, in China for the World Conference on Traditional Medicine 2024, said that traditional medicine in Afghanistan needs to be regulated and integrated into modern healthcare practices

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Afghanistan’s Acting Minister of Public Health has held in depth discussions on managing diseases such as malaria, tuberculosis, and polio with China’s Deputy Director for Disease Control and Prevention, Shen Hongbing. 

On an official visit to China, Mawlawi Noor Jalal Jalali also discussed other issues, with Shen and other officials, such as monitoring of diseases, disaster management processes and capacity building for Afghan healthcare workers.

Jalali, who was in China for the World Conference on Traditional Medicine 2024, also toured China’s Disease Control and Prevention Center (CDC) and its National Influenza Center.

The conference, which was held on Tuesday and Wednesday in Beijing, was jointly held by the World Health Organization (WHO) and Chinese sponsors, including China’s National Health Commission.

The opening ceremony of the two-day event was attended by health officials of governments and international organizations, experts and scholars, and deputies from medical institutions. 

WHO Director-General Tedros Adhanom Ghebreyesus gave a speech via video.

Addressing delegates at the conference, the ministry cited Jalali as having said that traditional medicine in Afghanistan needs to be regulated and integrated into modern healthcare practices.

He also advocated for strengthened bilateral cooperation between China and Afghanistan to enhance capacity building, experience sharing, and joint research in the sector.

Afghanistan’s health ministry has meanwhile established a Traditional Medicine Department which is currently tasked with formulating policies and guidelines to regulate and improve this sector.

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WHO reports 283% increase in polio cases in Afghanistan this year

Since the last WHO Emergency Committee meeting, in July this year, 51 new wild polio cases were reported – 17 from Afghanistan and 34 from Pakistan – bringing the total to 62 in 2024

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The World Health Organization (WHO) on Tuesday reported at an Emergency Committee meeting on the spread of polio that Afghanistan has recorded a 283% increase in polio cases in in the country this year. 

According to a statement issued by WHO, since the last Emergency Committee meeting, in July this year, 51 new wild polio cases were reported – 17 from Afghanistan and 34 from Pakistan – bringing the total to 62 in 2024. 

This represents a 283% increase in paralytic cases in Afghanistan and a 550% increase in Pakistan compared to all of 2023, WHO reported.

WHO stated there has been an upward trend of wild polio detection in Pakistan since mid-2023, mostly from Khyber Pakhtunkhwa, Sindh and Balochistan provinces. 

In Afghanistan, there has been an increase mainly in the south since late last year 2023.

The emergency meeting to address the surge in polio cases was held on November 6, 2024, and chaired by the WHO Director-General. The statement however, was only released on Tuesday, December 3.

WHO noted that both countries had implemented two nationwide vaccination campaign rounds in 2024. Afghanistan has however implemented an additional four and Pakistan an additional six sub-national vaccination rounds. 

“After very encouraging progress towards implementing house-to-house campaigns in all of Afghanistan during the first half of 2024, Afghanistan programme has recently gone back to implementing site-to-site modality campaigns. 

“The Committee was concerned about this recent development, since site-to-site campaigns are not able to reach all the children in Afghanistan especially those of younger age and girls, which may lead to a further upsurge of WPV1 (wild polio) with geographical spread in Afghanistan and beyond,” the statement read. 

WHO stated that in addition to seasonal movement patterns within and between the two endemic countries, the continued return of undocumented migrants from Pakistan to Afghanistan was compounding the challenges. 

“The scale of the displacement increases the risk of cross-border poliovirus spread as well as spread within both the countries. 

“This risk is being managed and mitigated in both countries through vaccination at border crossing points and the updating of micro-plans in the districts of origin and return. The programme continues to closely coordinate with IOM and UNHCR,” the statement read.

The organization emphasized the need for more comprehensive vaccination efforts to prevent further spread of the disease and for the international community to step up efforts to help the two countries eliminate the virus.

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