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U.S. man recovering after ‘breakthrough’ pig-heart transplant

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A U.S. man with terminal heart disease was implanted with a genetically modified pig heart in a first-of-its-kind surgery, and three days later the patient is doing well, his doctors reported on Monday.

The surgery, performed by a team at the University of Maryland Medicine, is among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene editing tools, Reuters reported.

If proven successful, scientists hope pig organs could help alleviate shortages of donor organs.

“This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients,” Dr. Bartley Griffith, who surgically transplanted the pig heart into the patient, said in a statement.

“We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,” Griffith added.

According to the report for 57-year-old David Bennett of Maryland, the heart transplant was his last option.

"It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” Bennett said a day before his surgery, according to a statement released by the university.

To move ahead with the experimental surgery, the university obtained an emergency authorization from the U.S. Food and Drug Administration on New Year's Eve through its compassionate use program.

"The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options,” said Dr. Muhammad Mohiuddin, who heads the University's program on xenotransplantation - transplanting animal organs into humans.

About 110,000 Americans are currently waiting for an organ transplant, and more than 6,000 patients die each year before getting one, according to organdonor.gov.

Bennett's genetically modified pig heart was provided by Revivicor, a regenerative medicine company based in Blacksburg, Virginia. On the morning of the surgery, the transplant team removed the pig's heart and placed it into a special device to preserve its function until the surgery, read the report.

Pigs have long been a tantalizing source of potential transplants because their organs are so similar to humans. A hog heart at the time of slaughter, for example, is about the size of an adult human heart.

Other organs from pigs being researched for transplantation into humans include kidneys, liver and lungs.

According to Reuters prior efforts at pig-to-human transplants have failed because of genetic differences that caused organ rejection or viruses that posed an infection risk.

Scientists have tackled that problem by editing away potentially harmful genes.

In the heart implanted in Bennett, three genes previously linked with organ rejection were "knocked out" of the donor pig, and six human genes linked with immune acceptance were inserted into the pig genome.

Researchers also deleted a pig gene to prevent excessive growth of the pig heart tissue.

The work was funded in part with a $15.7 million research grant to evaluate Revivicor's genetically-modified pig hearts in baboon studies.

In addition to the genetic changes to the pig heart, Bennett received an experimental anti-rejection drug made by Kiniksa Pharmaceuticals based in Lexington, Mass.

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Excluding Afghan women from medical institutes threatens the future of health care in the country: MSF

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The Islamic Emirate of Afghanistan’s (IEA) decision to bar women from studying in medical institutes will have far-reaching consequences for women’s health in the country, Médecins Sans Frontières (Doctors Without Borders) said on Friday.

This is another stage in the removal of women from public and professional life in Afghanistan. Already, there is an insufficient number of female health care workers in the country, impacting the availability of health care, especially given the separation of hospital wards by gender. New constraints will further restrict access to quality health care and pose serious dangers to its availability in the future, MSF said in a statement.

“There is no health care system without educated female health practitioners,” said Mickael Le Paih, MSF’s country representative in Afghanistan. “At MSF, more than 50 percent of our medical staff are women. The decision to bar women from studying at medical institutes will further exclude them from both education and the impartial provision of health care.”

The medical needs in Afghanistan are huge, and more female Afghan medical staff need to be trained to address them. For this to happen, women need to have access to education. Education restrictions for women and girls put in place in 2024, 2022, and 2021 considerably reduce the number of female medical staff in the future, MSF said.

“If no girls can attend secondary school, and no women can attend university or medical institutes, where will the female health professionals of the future come from and who will attend to Afghan women when they are at their most vulnerable?” said Le Paih. “For essential services to be available to all genders, they must be delivered by all genders.”

Recently, there have been reports that the leader of the Islamic Emirate has ordered the closure of medical institutes to women. The Islamic Emirate has not yet officially commented on this matter.

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Afghanistan’s health minister visits disease control center during China visit

Jalali, in China for the World Conference on Traditional Medicine 2024, said that traditional medicine in Afghanistan needs to be regulated and integrated into modern healthcare practices

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Afghanistan’s Acting Minister of Public Health has held in depth discussions on managing diseases such as malaria, tuberculosis, and polio with China’s Deputy Director for Disease Control and Prevention, Shen Hongbing. 

On an official visit to China, Mawlawi Noor Jalal Jalali also discussed other issues, with Shen and other officials, such as monitoring of diseases, disaster management processes and capacity building for Afghan healthcare workers.

Jalali, who was in China for the World Conference on Traditional Medicine 2024, also toured China’s Disease Control and Prevention Center (CDC) and its National Influenza Center.

The conference, which was held on Tuesday and Wednesday in Beijing, was jointly held by the World Health Organization (WHO) and Chinese sponsors, including China’s National Health Commission.

The opening ceremony of the two-day event was attended by health officials of governments and international organizations, experts and scholars, and deputies from medical institutions. 

WHO Director-General Tedros Adhanom Ghebreyesus gave a speech via video.

Addressing delegates at the conference, the ministry cited Jalali as having said that traditional medicine in Afghanistan needs to be regulated and integrated into modern healthcare practices.

He also advocated for strengthened bilateral cooperation between China and Afghanistan to enhance capacity building, experience sharing, and joint research in the sector.

Afghanistan’s health ministry has meanwhile established a Traditional Medicine Department which is currently tasked with formulating policies and guidelines to regulate and improve this sector.

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WHO reports 283% increase in polio cases in Afghanistan this year

Since the last WHO Emergency Committee meeting, in July this year, 51 new wild polio cases were reported – 17 from Afghanistan and 34 from Pakistan – bringing the total to 62 in 2024

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The World Health Organization (WHO) on Tuesday reported at an Emergency Committee meeting on the spread of polio that Afghanistan has recorded a 283% increase in polio cases in in the country this year. 

According to a statement issued by WHO, since the last Emergency Committee meeting, in July this year, 51 new wild polio cases were reported – 17 from Afghanistan and 34 from Pakistan – bringing the total to 62 in 2024. 

This represents a 283% increase in paralytic cases in Afghanistan and a 550% increase in Pakistan compared to all of 2023, WHO reported.

WHO stated there has been an upward trend of wild polio detection in Pakistan since mid-2023, mostly from Khyber Pakhtunkhwa, Sindh and Balochistan provinces. 

In Afghanistan, there has been an increase mainly in the south since late last year 2023.

The emergency meeting to address the surge in polio cases was held on November 6, 2024, and chaired by the WHO Director-General. The statement however, was only released on Tuesday, December 3.

WHO noted that both countries had implemented two nationwide vaccination campaign rounds in 2024. Afghanistan has however implemented an additional four and Pakistan an additional six sub-national vaccination rounds. 

“After very encouraging progress towards implementing house-to-house campaigns in all of Afghanistan during the first half of 2024, Afghanistan programme has recently gone back to implementing site-to-site modality campaigns. 

“The Committee was concerned about this recent development, since site-to-site campaigns are not able to reach all the children in Afghanistan especially those of younger age and girls, which may lead to a further upsurge of WPV1 (wild polio) with geographical spread in Afghanistan and beyond,” the statement read. 

WHO stated that in addition to seasonal movement patterns within and between the two endemic countries, the continued return of undocumented migrants from Pakistan to Afghanistan was compounding the challenges. 

“The scale of the displacement increases the risk of cross-border poliovirus spread as well as spread within both the countries. 

“This risk is being managed and mitigated in both countries through vaccination at border crossing points and the updating of micro-plans in the districts of origin and return. The programme continues to closely coordinate with IOM and UNHCR,” the statement read.

The organization emphasized the need for more comprehensive vaccination efforts to prevent further spread of the disease and for the international community to step up efforts to help the two countries eliminate the virus.

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