Connect with us

Science & Technology

Scientists grow human brain cells in rats to study diseases

Published

on

(Last Updated On: )

Scientists have transplanted human brain cells into the brains of baby rats, where the cells grew and formed connections.

It’s part of an effort to better study human brain development and diseases affecting this most complex of organs, which makes us who we are but has long been shrouded in mystery.

“Many disorders such as autism and schizophrenia are likely uniquely human” but “the human brain certainly has not been very accessible,” said said Dr. Sergiu Pasca, senior author of a study describing the work, published Wednesday in the journal Nature.

Approaches that don’t involve taking tissue out of the human brain are “promising avenues in trying to tackle these conditions.”

The research builds upon the team’s previous work creating brain “organoids,” tiny structures resembling human organs that have also been made to represent others such as livers, kidneys, prostates, or key parts of them.

To make the brain organoids, Stanford University scientists transformed human skin cells into stem cells and then coaxed them to become several types of brain cells. Those cells then multiplied to form organoids resembling the cerebral cortex, the human brain’s outermost layer, which plays a key role in things like memory, thinking, learning, reasoning and emotions.

Scientists transplanted those organoids into rat pups 2 to 3 days old, a stage when brain connections are still forming. The organoids grew so that they eventually occupied a third of the hemisphere of the rat’s brain where they were implanted. Neurons from the organoids formed working connections with circuits in the brain.

Human neurons have been transplanted in rodents before, but generally in adult animals, usually mice. Pasca, a psychiatry professor at the Stanford School of Medicine, said this is the first time these organoids have been placed into early rat brains, creating “the most advanced human brain circuitry ever built from human skin cells and a demonstration that implanted human neurons can influence an animal’s behavior.”

To examine a practical use of this approach, scientists transplanted organoids into both sides of a rat’s brain: one generated from a healthy person’s cells and another from the cells of a person with Timothy syndrome, a rare genetic condition associated with heart problems and autism spectrum disorder.

Five to six months later, they saw effects of the disease related to the activity of the neurons. There were differences in the two sides’ electrical activity, and the neurons from the person with Timothy syndrome were much smaller and didn’t sprout as many extensions that pick up input from nearby neurons.

Researchers, whose study was funded partly by the National Institutes of Health, said they could do the same sorts of experiments using organoids made from the cells of people with disorders such as autism or schizophrenia — and potentially learn new things about how these conditions affect the brain, too.

Dr. Flora Vaccarino of Yale University – who previously grew lumps containing cerebral cortex that were made with DNA from people with autism – said the study moves the field forward.

Such experiments in animals raise ethical concerns. For example, Pasca said he and his team are cognizant of the rats’ well-being and whether they still behave normally with the organoids inside them, which he says they do. Still, Pasca does not believe this should be tried in primates. Ethicists also wonder about the possibility of brain organoids in the future attaining something like human consciousness, which experts say is extremely unlikely now.

Some scientists are studying human brain organoids outside of animals. For example, researchers at ETH Zurich in Switzerland published a study in Nature earlier this month describing how they are growing brain-like tissue from stem cells in the lab and then mapping the cell types in various brain regions and genes regulating their development. Some are using these structures to study autism.

Science & Technology

‘Massive cyberattack’ brings down Elon Musk’s X

Digital Trends reported Tuesday that there are reports suggesting X is still having issues

Published

on

(Last Updated On: )

Social media platform X went down intermittently on Monday, with owner Elon Musk blaming an unusually powerful cyberattack.

“We get attacked every day, but this was done with a lot of resources. Either a large, coordinated group and/or a country is involved,” Musk said in a post on X on Monday.

He did not clarify exactly what he meant by “a lot of resources” and his comments drew skepticism from cybersecurity specialists, who pointed out that attacks of this nature — called denials of service — have repeatedly been executed by small groups or individuals.

X faced intermittent outages, according to Downdetector, Reuters reported.

Digital Trends meanwhile reported Tuesday that there are reports suggesting X is still having issues. 

Internet industry experts have said X was hit by several waves of ‘denial of service’ throughout Monday. 

Musk said in an interview with Fox Business Network’s Larry Kudlow the cyberattack came from IP addresses originating in the Ukraine area.

An industry source told Reuters he disputed Musk’s account, saying that large chunks of the rogue traffic bombarding X could be traced back to IP addresses in the United States, Vietnam, Brazil and other countries, and that the amount of rogue traffic coming directly from Ukraine was “insignificant.”

In any case, denial of service attacks are notoriously hard to trace back to their authors and the IP addresses involved rarely provide any meaningful insight into who was behind them, Reuters reported.

Musk has joined U.S. President Donald Trump, whom he serves as an adviser, in criticizing Ukraine’s continued efforts to fight off a Russian invasion. 

Musk said on Sunday that Ukraine’s front line “would collapse” without his Starlink satellite communications service, though he said he would not cut off Ukraine’s access to it.

Continue Reading

Science & Technology

NASA says ‘city killer’ asteroid has a 3.1 % chance of striking Earth in 2032

Despite the rising odds, experts say there is no need for alarm

Published

on

City killer asteroid
(Last Updated On: )

An asteroid that could level a city now has a 3.1-percent chance of striking Earth in 2032, according to NASA data released Tuesday — making it the most threatening space rock ever recorded by modern forecasting.

Despite the rising odds, experts say there is no need for alarm. The global astronomical community is closely monitoring the situation and the James Webb Space Telescope is set to fix its gaze on the object, known as 2024 YR4, next month.

“I’m not panicking,” Bruce Betts, chief scientist for the nonprofit Planetary Society told AFP.

“Naturally when you see the percentages go up, it doesn’t make you feel warm and fuzzy and good,” he added, but explained that as astronomers gather more data, the probability will likely edge up before rapidly dropping to zero.

2024 YR4 was first detected on December 27 last year by the El Sauce Observatory in Chile.

Astronomers estimate its size to be between 130 and 300 feet (40–90 meters) wide, based on its brightness. Analysis of its light signatures suggests it has a fairly typical composition, rather than being a rare metal-rich asteroid.

The International Asteroid Warning Network (IAWN), a worldwide planetary defense collaboration, issued a warning memo on January 29 after the impact probability had crossed one percent. Since then, the figure has fluctuated but continues to trend upward.

NASA’s latest calculations estimate the impact probability at 3.1 percent, up from 1.6 percent last month, with a potential Earth impact date of December 22, 2032.

Richard Moissl, head of the European Space Agency’s planetary defense office, which puts the risk slightly lower at 2.8 percent told AFP that  this “is not a crisis at this point in time. This is not the dinosaur killer. This is not the planet killer. This is at most dangerous for a city.”

If the risk rises over 10 percent, IAWN would issue a formal warning, leading to a “recommendation for all UN members who have territories in potentially threatened areas to start terrestrial preparedness,” explained Moissl.

Unlike the six-mile-wide (10-kilometer-wide) asteroid that wiped out the dinosaurs 66 million years ago, 2024 YR4 is classified as a “city killer” — not a global catastrophe, but still capable of causing significant destruction.

Its potential devastation comes less from its size and more from its velocity, which could be nearly 40,000 miles per hour if it hits.

If it enters Earth’s atmosphere, the most likely scenario is an airburst, meaning it would explode midair with a force of approximately eight megatons of TNT — more than 500 times the power of the Hiroshima bomb.

But an impact crater cannot be ruled out if the size is closer to the higher end of estimates, said Betts.

The potential impact corridor spans the eastern Pacific, northern South America, the Atlantic, Africa, the Arabian Peninsula, and South Asia — though Moissl emphasized it is far too early for people to consider drastic decisions like relocation.

The good news: there’s ample time to act.

NASA’s 2022 DART mission proved that spacecraft can successfully alter an asteroid’s path, and scientists have theorized other methods, such as using lasers to create thrust by vaporizing part of the surface, pulling it off course with a spacecraft’s gravity, or even using nuclear explosions as a last resort. — Agence France-Presse

 

Continue Reading

Science & Technology

Panjshir will soon be connected to national fiber optic network

The statement said that this project covers a 36-kilometer route from Gulbahar to Bazarak, and the districts of Shatal, Anaba and Rukha will also benefit from fiber optic services.

Published

on

(Last Updated On: )

The Panjshir provincial media office said in a statement on Wednesday, February 1 that practical work was to connect the province to fiber optic will begin within the next month.

The statement said that this project covers a 36-kilometer route from Gulbahar to Bazarak, and the districts of Shatal, Anaba and Rukha will also benefit from fiber optic services.

The statement added that the project is being implemented by Afghan Wireless, Afghan Telecom and ICG companies as a result of the efforts of the Panjshir provincial administration and the special attention of the leadership of the Ministry of Communications and Information Technology of the Islamic Emirate of Afghanistan.

Continue Reading

Trending

Copyright © 2024 Ariana News. All rights reserved!