The conference is expected to see attendance of leaders from around 30 countries including US, Russia, China and Iran.
The theme will be connectivity and increasing security in and around the Afghan region.
The discussions will revolve primarily on peace, cooperation and economic growth in Afghanistan and neighboring regions.
India is the co-chair and host this time and Afghanistan is the permanent chair of the conference.
President Mohammad Ashraf Ghani and Indian Prime Minister Narendra Modi will reach at the conference on Saturday evening.
According to the reports, the two leaders are also likely to hold bilateral talks to strengthen India-Afghanistan ties.
Modi and Ghani will jointly inaugurate the ministerial deliberations of Heart of Asia-Istanbul Process.