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First babies born in Britain using DNA from 3 people

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Britain’s fertility regulator on Wednesday confirmed the births of the U.K.’s first babies created using an experimental technique combining DNA from three people, an effort to prevent the children from inheriting rare genetic diseases.

Britain’s Human Fertilization and Embryology Authority said fewer than five babies have been born this way in the U.K. but did not provide further details to protect the families’ identities, Associated Press reported. The news was first reported by the Guardian newspaper.

In 2015, the U.K. became the world’s first country to adopt legislation specifically regulating methods to help prevent women with faulty mitochondria — the energy source in a cell — from passing defects on to their babies.

The genetic defects can result in diseases such as muscular dystrophy, epilepsy, heart problems and intellectual disabilities. About one in 200 children in Britain is born with a mitochondrial disorder. To date, 32 patients have been authorized to receive such treatment.

For a woman with faulty mitochondria, scientists take genetic material from her egg or embryo, which is then transferred into a donor egg or embryo that still has healthy mitochondria but had the rest of its key DNA removed.

The fertilized embryo is then transferred into the womb of the mother. The genetic material from the donated egg comprises less than 1% of the child created from this technique.

“Mitochondrial donation treatment offers families with severe inherited mitochondrial illness the possibility of a healthy child,” the U.K. fertility regulator said in a statement Wednesday. The agency said it was still “early days” but it hoped the scientists involved, at Newcastle University, would soon publish details of the treatment.

Britain requires every woman undergoing the treatment to receive approval from the Human Fertilization and Embryology Authority. The regulator says that to be eligible, families must have no other available options for avoiding passing on genetic disease.

Many critics oppose the artificial reproduction techniques, arguing there are other ways for people to avoid passing on diseases to their children, such as egg donation or screening tests, and that the experimental methods have not yet been proven safe.

Others warn that tweaking the genetic code this way could be a slippery slope that eventually leads to designer babies for parents who not only want to avoid inherited diseases but to have taller, stronger, smarter or better-looking children.

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Excluding Afghan women from medical institutes threatens the future of health care in the country: MSF

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The Islamic Emirate of Afghanistan’s (IEA) decision to bar women from studying in medical institutes will have far-reaching consequences for women’s health in the country, Médecins Sans Frontières (Doctors Without Borders) said on Friday.

This is another stage in the removal of women from public and professional life in Afghanistan. Already, there is an insufficient number of female health care workers in the country, impacting the availability of health care, especially given the separation of hospital wards by gender. New constraints will further restrict access to quality health care and pose serious dangers to its availability in the future, MSF said in a statement.

“There is no health care system without educated female health practitioners,” said Mickael Le Paih, MSF’s country representative in Afghanistan. “At MSF, more than 50 percent of our medical staff are women. The decision to bar women from studying at medical institutes will further exclude them from both education and the impartial provision of health care.”

The medical needs in Afghanistan are huge, and more female Afghan medical staff need to be trained to address them. For this to happen, women need to have access to education. Education restrictions for women and girls put in place in 2024, 2022, and 2021 considerably reduce the number of female medical staff in the future, MSF said.

“If no girls can attend secondary school, and no women can attend university or medical institutes, where will the female health professionals of the future come from and who will attend to Afghan women when they are at their most vulnerable?” said Le Paih. “For essential services to be available to all genders, they must be delivered by all genders.”

Recently, there have been reports that the leader of the Islamic Emirate has ordered the closure of medical institutes to women. The Islamic Emirate has not yet officially commented on this matter.

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Afghanistan’s health minister visits disease control center during China visit

Jalali, in China for the World Conference on Traditional Medicine 2024, said that traditional medicine in Afghanistan needs to be regulated and integrated into modern healthcare practices

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Afghanistan’s Acting Minister of Public Health has held in depth discussions on managing diseases such as malaria, tuberculosis, and polio with China’s Deputy Director for Disease Control and Prevention, Shen Hongbing. 

On an official visit to China, Mawlawi Noor Jalal Jalali also discussed other issues, with Shen and other officials, such as monitoring of diseases, disaster management processes and capacity building for Afghan healthcare workers.

Jalali, who was in China for the World Conference on Traditional Medicine 2024, also toured China’s Disease Control and Prevention Center (CDC) and its National Influenza Center.

The conference, which was held on Tuesday and Wednesday in Beijing, was jointly held by the World Health Organization (WHO) and Chinese sponsors, including China’s National Health Commission.

The opening ceremony of the two-day event was attended by health officials of governments and international organizations, experts and scholars, and deputies from medical institutions. 

WHO Director-General Tedros Adhanom Ghebreyesus gave a speech via video.

Addressing delegates at the conference, the ministry cited Jalali as having said that traditional medicine in Afghanistan needs to be regulated and integrated into modern healthcare practices.

He also advocated for strengthened bilateral cooperation between China and Afghanistan to enhance capacity building, experience sharing, and joint research in the sector.

Afghanistan’s health ministry has meanwhile established a Traditional Medicine Department which is currently tasked with formulating policies and guidelines to regulate and improve this sector.

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WHO reports 283% increase in polio cases in Afghanistan this year

Since the last WHO Emergency Committee meeting, in July this year, 51 new wild polio cases were reported – 17 from Afghanistan and 34 from Pakistan – bringing the total to 62 in 2024

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The World Health Organization (WHO) on Tuesday reported at an Emergency Committee meeting on the spread of polio that Afghanistan has recorded a 283% increase in polio cases in in the country this year. 

According to a statement issued by WHO, since the last Emergency Committee meeting, in July this year, 51 new wild polio cases were reported – 17 from Afghanistan and 34 from Pakistan – bringing the total to 62 in 2024. 

This represents a 283% increase in paralytic cases in Afghanistan and a 550% increase in Pakistan compared to all of 2023, WHO reported.

WHO stated there has been an upward trend of wild polio detection in Pakistan since mid-2023, mostly from Khyber Pakhtunkhwa, Sindh and Balochistan provinces. 

In Afghanistan, there has been an increase mainly in the south since late last year 2023.

The emergency meeting to address the surge in polio cases was held on November 6, 2024, and chaired by the WHO Director-General. The statement however, was only released on Tuesday, December 3.

WHO noted that both countries had implemented two nationwide vaccination campaign rounds in 2024. Afghanistan has however implemented an additional four and Pakistan an additional six sub-national vaccination rounds. 

“After very encouraging progress towards implementing house-to-house campaigns in all of Afghanistan during the first half of 2024, Afghanistan programme has recently gone back to implementing site-to-site modality campaigns. 

“The Committee was concerned about this recent development, since site-to-site campaigns are not able to reach all the children in Afghanistan especially those of younger age and girls, which may lead to a further upsurge of WPV1 (wild polio) with geographical spread in Afghanistan and beyond,” the statement read. 

WHO stated that in addition to seasonal movement patterns within and between the two endemic countries, the continued return of undocumented migrants from Pakistan to Afghanistan was compounding the challenges. 

“The scale of the displacement increases the risk of cross-border poliovirus spread as well as spread within both the countries. 

“This risk is being managed and mitigated in both countries through vaccination at border crossing points and the updating of micro-plans in the districts of origin and return. The programme continues to closely coordinate with IOM and UNHCR,” the statement read.

The organization emphasized the need for more comprehensive vaccination efforts to prevent further spread of the disease and for the international community to step up efforts to help the two countries eliminate the virus.

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