A senior White House official on Thursday said nuclear-armed Pakistan is developing long-range ballistic missile capabilities that eventually could allow it to strike targets well beyond South Asia, making it an "emerging threat" to the United States.

Deputy National Security Adviser Jon Finer's surprise revelation underscored how far the once-close ties between Washington and Islamabad have deteriorated since the 2021 U.S. troop withdrawal from Afghanistan, Reuters reported.

It also raised questions about whether Pakistan has shifted the objectives of nuclear weapons and ballistic missile programs long intended to counter those of India, with which it has fought three major wars since 1947.

Speaking to the Carnegie Endowment for International Peace, Finer said Pakistan has pursued "increasingly sophisticated missile technology, from long-range ballistic missile systems to equipment, that would enable the testing of significantly larger rocket motors."

If those trends continue, Finer said, "Pakistan will have the capability to strike targets well beyond South Asia, including in the United States."

The number of nuclear-armed states with missiles that can reach the U.S. homeland "is very small and they tend to be adversarial," he continued, naming Russia, North Korea and China.

"So, candidly, it's hard for us to see Pakistan's actions as anything other than an emerging threat to the United States," Finer said.

His speech came a day after Washington announced a new round of sanctions related to Pakistan's ballistic missile development program, including for the first time against the state-run defense agency that oversees the program.

The Pakistani embassy did not immediately respond to a request for comment.

Islamabad casts its nuclear weapons and ballistic missile programs as deterrents against Indian aggression and intended to maintain regional stability.

Two senior administration officials, speaking on condition of anonymity, said that the U.S. concerns with Pakistan's missile program have been long-standing and stemmed from the sizes of the rocket engines being developed.

The threat posed to the United States is up to a decade away, said one official.

Finer's comments, the officials said, were intended to press Pakistani officials to address why they are developing more powerful rocket engines, something they have refused to do.

"They don't acknowledge our concerns. They tell us we are biased," said the second U.S. official, adding that Pakistani officials have wrongly implied that U.S. sanctions on their missile program are intended "to handicap their ability to defend against India."

Finer included himself among senior U.S. officials who he said repeatedly have raised concerns about the missile program with top Pakistani officials to no avail.

Washington and Islamabad, he noted, had been "long-time partners" on development, counter-terrorism and security.

"That makes us question even more why Pakistan will be motivated to develop a capability that could be used against us."

Pakistan has been critical of warm ties U.S. President Joe Biden has forged with its long-time foe India, and maintains close ties with China. Some Chinese entities have been slapped with U.S. sanctions for supplying Islamabad's ballistic missile program.

It conducted its first nuclear weapons test in 1998 - more than 20 years after India's first test blast - and has built an extensive arsenal of ballistic missiles capable of lofting nuclear warheads.

The Bulletin of the American Scientists research organization estimates that Pakistan has a stockpile of about 170 warheads.

U.S.-Pakistani relations have undergone major ups and downs, including close Cold War ties that saw them support Afghan rebels against the 1979-89 Soviet occupation of Afghanistan.

Pakistan also was a key partner in the U.S. fight against al Qaeda following the Sept. 11, 2001, attacks on the United States, and has been a major non-NATO ally since 2004.

But ties also have been hurt by coups staged by the Pakistani military, its support for the Islamic Emirate's 1996-2001 rule and its nuclear weapons program.

Several experts said Finer's speech came as a major surprise.

"For a senior U.S. official to publicly link concerns about proliferation in Pakistan to a future direct threat to the U.S. homeland - this is a mighty dramatic development," said Michael Kugelman of the Wilson Center think tank.

The United States, joined by Arab mediators, sought to conclude an agreement between Israel and Hamas to halt the 14-month-old war in the Gaza Strip, where medics said Israeli strikes killed at least 20 Palestinians on Wednesday.

A Palestinian official close to the negotiations said on Wednesday that mediators had narrowed gaps on most of the agreement's clauses. He said Israel had introduced conditions which Hamas rejected but would not elaborate.

On Tuesday, sources close to the talks in Cairo, the Egyptian capital, said an agreement could be signed in coming days on a ceasefire and a release of hostages held in Gaza in return for Palestinian prisoners held by Israel.

Medics said an Israeli airstrike killed at least 10 people in a house in the northern town of Beit Lahiya while six were killed in separate airstrikes in Gaza City, Nuseirat camp in central areas, and Rafah near the border with Egypt.

In Beit Hanoun in the northern Gaza Strip, medics said four people were killed in an airstrike on a house. There was no immediate comment from the Israeli military spokesman.

Later on Wednesday, medics told Reuters that an Israeli strike on a house in Jabalia killed at least 10 people.

Israeli forces have operated in the towns of Beit Hanoun and Beit Lahiya as well as the nearby Jabalia camp since October, in a campaign the military said aimed to prevent Hamas militants from regrouping.

Palestinians accuse Israel of carrying out acts of "ethnic cleansing" to depopulate the northern edge of the enclave to create a buffer zone. Israel denies it.

Hamas does not disclose its casualties, and the Palestinian health ministry does not distinguish in its daily death toll between combatants and non-combatants.

On Wednesday, the Israeli military said it struck a number of Hamas militants planning an imminent attack against Israeli forces operating in Jabalia.

Later on Wednesday, Muhammad Saleh, director of Al-Awda Hospital in Jabalia, said Israeli shelling in the vicinity damaged the facility, wounding seven medics and one patient inside the hospital.

The Israeli military had no immediate comment.

In the Central Gaza camp of Bureij, Palestinian families began leaving some districts after the army posted new evacuation orders on X and in written and audio messages to mobile phones of some of the population there, citing new firing of rockets by Palestinian militants from the area.

CEASEFIRE GAINS MOMENTUM

The U.S. administration, joined by mediators from Egypt and Qatar, has made intensive efforts in recent days to advance the talks before President Joe Biden leaves office next month.

In Jerusalem, Israeli President Isaac Herzog met Adam Boehler, U.S. President-elect Donald Trump’s designated envoy for hostage affairs. Trump has threatened that "all hell is going to break out" if Hamas does not release its hostages by Jan. 20, the day Trump returns to the White House.

CIA Director William Burns was due in Doha on Wednesday for talks with Qatari Prime Minister Sheikh Mohammed bin Abdulrahman Al Thani on bridging remaining gaps between Israel and Hamas, other knowledgeable sources said. The CIA declined to comment.

Israeli negotiators were in Doha on Monday looking to bridge gaps between Israel and Hamas on a deal Biden outlined in May.

There have been repeated rounds of talks over the past year, all of which have failed, with Israel insisting on retaining a military presence in Gaza and Hamas refusing to release hostages until the troops pulled out.

The war in Gaza, triggered by a Hamas-led attack on communities in southern Israel that killed some 1,200 people and saw more than 250 abducted as hostages, has sent shockwaves across the Middle East and left Israel isolated internationally.

Israel's campaign has killed more than 45,000 Palestinians, displaced most of the 2.3 million population and reduced much of the coastal enclave to ruins.