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Pig heart transplanted into human patient for the second time

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Surgeons have transplanted a pig’s heart into a dying man in a bid to prolong his life – only the second patient to ever undergo such an experimental feat. Two days later, the man was cracking jokes and able to sit in a chair, Maryland doctors said Friday.

The 58-year-old Navy veteran was facing near-certain death from heart failure but other health problems meant he wasn’t eligible for a traditional heart transplant, according to doctors at University of Maryland Medicine, the Associated Press reported.

“Nobody knows from this point forward. At least now I have hope and I have a chance,” Lawrence Faucette, from Frederick, Maryland, said in a video recorded by the hospital before Wednesday’s operation. “I will fight tooth and nail for every breath I can take.”

While the next few weeks will be critical, doctors were thrilled at Faucette’s early response to the pig organ.

“You know, I just keep shaking my head – how am I talking to someone who has a pig heart?” Dr. Bartley Griffith, who performed the transplant, told The Associated Press. He said doctors are feeling “a great privilege but, you know, a lot of pressure.”

The same Maryland team last year performed the world's first transplanet of a genetically modified pig heart into another dying man, David Bennett, who survived just two months.

There’s a huge shortage of human organs donated for transplant. Last year, there were just over 4,100 heart transplants in the U.S., a record number but the supply is so tight that only patients with the best chance of long-term survival get offered one.

Attempts at animal-to-human organ transplants have failed for decades, as people’s immune systems immediately destroyed the foreign tissue. Now scientists are trying again using pigs genetically modified to make their organs more humanlike.

Recently, scientists at other hospitals have tested pig kidneys and hearts in donated human bodies, hoping to learn enough to begin formal studies of what are called xenotransplants.

To make this new attempt in a living patient outside of a rigorous trial, the Maryland researchers required special permission from the Food and Drug Administration, under a process reserved for certain emergency cases with no other options.

It took over 300 pages of documents filed with FDA, but the Maryland researchers made their case that they’d learned enough from their first attempt last year – even though that patient died for reasons that aren’t fully understood – that it made sense to try again.

And Faucette, who retired as a lab technician at the National Institutes of Health, had to agree that he understood the procedure’s risks.

In a statement his wife, Ann Faucette, said: “We have no expectations other than hoping for more time together. That could be as simple as sitting on the front porch and having coffee together.”

What’s different this time: Only after last year’s transplant did scientists discover signs of a pig virus lurking inside the heart – and they now have better tests to look for hidden viruses. They also made some medication changes.

Possibly more important, while Faucette has end-stage heart failure and was out of other options, he wasn’t as near death as the prior patient.

By Friday, his new heart was functioning well without any supportive machinery, the hospital said.

“It’s just an amazing feeling to see this pig heart work in a human,” said Dr. Muhammad Mohiuddin, the Maryland team’s xenotransplantation expert. But, he cautioned, “we don’t want to predict anything. We will take every day as a victory and move forward.”

This kind of single-patient “compassionate use” can provide some information about how the pig organ works but not nearly as much as more formal testing, said Karen Maschke, a research scholar at the Hastings Center who is helping develop ethics and policy recommendations for xenotransplant clinical trials. That FDA allowed this second case “suggests that the agency is not ready to permit a pig heart clinical trial to start,” Mashke added.

The pig heart, provided by Blacksburg, Virginia-based Revivicor, has 10 genetic modifications – knocking out some pig genes and adding some human ones to make it more acceptable to the human immune system.

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Excluding Afghan women from medical institutes threatens the future of health care in the country: MSF

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The Islamic Emirate of Afghanistan’s (IEA) decision to bar women from studying in medical institutes will have far-reaching consequences for women’s health in the country, Médecins Sans Frontières (Doctors Without Borders) said on Friday.

This is another stage in the removal of women from public and professional life in Afghanistan. Already, there is an insufficient number of female health care workers in the country, impacting the availability of health care, especially given the separation of hospital wards by gender. New constraints will further restrict access to quality health care and pose serious dangers to its availability in the future, MSF said in a statement.

“There is no health care system without educated female health practitioners,” said Mickael Le Paih, MSF’s country representative in Afghanistan. “At MSF, more than 50 percent of our medical staff are women. The decision to bar women from studying at medical institutes will further exclude them from both education and the impartial provision of health care.”

The medical needs in Afghanistan are huge, and more female Afghan medical staff need to be trained to address them. For this to happen, women need to have access to education. Education restrictions for women and girls put in place in 2024, 2022, and 2021 considerably reduce the number of female medical staff in the future, MSF said.

“If no girls can attend secondary school, and no women can attend university or medical institutes, where will the female health professionals of the future come from and who will attend to Afghan women when they are at their most vulnerable?” said Le Paih. “For essential services to be available to all genders, they must be delivered by all genders.”

Recently, there have been reports that the leader of the Islamic Emirate has ordered the closure of medical institutes to women. The Islamic Emirate has not yet officially commented on this matter.

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Afghanistan’s health minister visits disease control center during China visit

Jalali, in China for the World Conference on Traditional Medicine 2024, said that traditional medicine in Afghanistan needs to be regulated and integrated into modern healthcare practices

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Afghanistan’s Acting Minister of Public Health has held in depth discussions on managing diseases such as malaria, tuberculosis, and polio with China’s Deputy Director for Disease Control and Prevention, Shen Hongbing. 

On an official visit to China, Mawlawi Noor Jalal Jalali also discussed other issues, with Shen and other officials, such as monitoring of diseases, disaster management processes and capacity building for Afghan healthcare workers.

Jalali, who was in China for the World Conference on Traditional Medicine 2024, also toured China’s Disease Control and Prevention Center (CDC) and its National Influenza Center.

The conference, which was held on Tuesday and Wednesday in Beijing, was jointly held by the World Health Organization (WHO) and Chinese sponsors, including China’s National Health Commission.

The opening ceremony of the two-day event was attended by health officials of governments and international organizations, experts and scholars, and deputies from medical institutions. 

WHO Director-General Tedros Adhanom Ghebreyesus gave a speech via video.

Addressing delegates at the conference, the ministry cited Jalali as having said that traditional medicine in Afghanistan needs to be regulated and integrated into modern healthcare practices.

He also advocated for strengthened bilateral cooperation between China and Afghanistan to enhance capacity building, experience sharing, and joint research in the sector.

Afghanistan’s health ministry has meanwhile established a Traditional Medicine Department which is currently tasked with formulating policies and guidelines to regulate and improve this sector.

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WHO reports 283% increase in polio cases in Afghanistan this year

Since the last WHO Emergency Committee meeting, in July this year, 51 new wild polio cases were reported – 17 from Afghanistan and 34 from Pakistan – bringing the total to 62 in 2024

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The World Health Organization (WHO) on Tuesday reported at an Emergency Committee meeting on the spread of polio that Afghanistan has recorded a 283% increase in polio cases in in the country this year. 

According to a statement issued by WHO, since the last Emergency Committee meeting, in July this year, 51 new wild polio cases were reported – 17 from Afghanistan and 34 from Pakistan – bringing the total to 62 in 2024. 

This represents a 283% increase in paralytic cases in Afghanistan and a 550% increase in Pakistan compared to all of 2023, WHO reported.

WHO stated there has been an upward trend of wild polio detection in Pakistan since mid-2023, mostly from Khyber Pakhtunkhwa, Sindh and Balochistan provinces. 

In Afghanistan, there has been an increase mainly in the south since late last year 2023.

The emergency meeting to address the surge in polio cases was held on November 6, 2024, and chaired by the WHO Director-General. The statement however, was only released on Tuesday, December 3.

WHO noted that both countries had implemented two nationwide vaccination campaign rounds in 2024. Afghanistan has however implemented an additional four and Pakistan an additional six sub-national vaccination rounds. 

“After very encouraging progress towards implementing house-to-house campaigns in all of Afghanistan during the first half of 2024, Afghanistan programme has recently gone back to implementing site-to-site modality campaigns. 

“The Committee was concerned about this recent development, since site-to-site campaigns are not able to reach all the children in Afghanistan especially those of younger age and girls, which may lead to a further upsurge of WPV1 (wild polio) with geographical spread in Afghanistan and beyond,” the statement read. 

WHO stated that in addition to seasonal movement patterns within and between the two endemic countries, the continued return of undocumented migrants from Pakistan to Afghanistan was compounding the challenges. 

“The scale of the displacement increases the risk of cross-border poliovirus spread as well as spread within both the countries. 

“This risk is being managed and mitigated in both countries through vaccination at border crossing points and the updating of micro-plans in the districts of origin and return. The programme continues to closely coordinate with IOM and UNHCR,” the statement read.

The organization emphasized the need for more comprehensive vaccination efforts to prevent further spread of the disease and for the international community to step up efforts to help the two countries eliminate the virus.

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